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3. Akiyoshi R, ..., Yachie A. Noninvasive, label-free image approaches to predict multimodal molecular markers in pluripotency assessment. Sci Rep (2024 Jul 9)
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6. Barakat N, ..., Hickman J. Inhibition of Metalloproteinases Extends Longevity and Function of In Vitro Human iPSC-Derived Skeletal Muscle. Biomedicines (2024 Apr 12)
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12. Chung SK, ..., Chung SK. Single Nucleotide Polymorphism-based Identification of Bacterial Artificial Chromosome-mediated Homologous Recombination. Front Biosci (Landmark Ed) (2024 Aug 15)
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14. Culibrk RA, ..., Hahn MS. Impact of Suramin on Key Pathological Features of Sporadic Alzheimer's Disease-Derived Forebrain Neurons. J Alzheimers Dis (2024)
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15. DiFiglia M, ..., Thompson LM. Towards Standardizing Nomenclature in Huntington's Disease Research. J Huntingtons Dis (2024)
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16. Gallo LH, ..., Hickman JJ. A functional aged human iPSC-cortical neuron model recapitulates Alzheimer's disease, senescence, and the response to therapeutics. Alzheimers Dement (2024 Jul 30)
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17. Guha A, ..., King PH. The myokine FGF21 associates with enhanced survival in ALS and mitigates stress-induced cytotoxicity. bioRxiv (2024 Sep 14)
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18. Gustavsson EK, ..., Ryten M. The annotation of GBA1 has been concealed by its protein-coding pseudogene GBAP1. Sci Adv (2024 Jun 28)
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19. Hamilton HL, ..., Pehar M. FABP7 drives an inflammatory response in human astrocytes and is upregulated in Alzheimer's disease. Geroscience (2024 Apr)
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20. Hegde M, ..., Rao KS. Mitochondria-Targeted Oligomeric α-Synuclein Induces TOM40 Degradation and Mitochondrial Dysfunction in Parkinson's Disease and Parkinsonism-Dementia of Guam. Res Sq (2024 Feb 21)
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21. Hwang HY, ..., Kim D. Precise editing of pathogenic nucleotide repeat expansions in iPSCs using paired prime editor. Nucleic Acids Res (2024 Apr 25)
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22. Iwamoto N, ..., Vargeese C. Preclinical evaluation of stereopure antisense oligonucleotides for allele-selective lowering of mutant HTT. Mol Ther Nucleic Acids (2024 Sep 10)
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23. Jin M, ..., Jiang P. A Trisomy 21-linked Hematopoietic Gene Variant in Microglia Confers Resilience in Human iPSC Models of Alzheimer's Disease. bioRxiv (2024 Mar 14)
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24. Kim KH, ..., Lee JM. Posttranscriptional regulation of FAN1 by miR-124-3p at rs3512 underlies onset-delaying genetic modification in Huntington's disease. Proc Natl Acad Sci U S A (2024 Apr 16)
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25. Kim MJ, ..., Krainc D. Inhibition of cysteine protease cathepsin L increases the level and activity of lysosomal glucocerebrosidase. JCI Insight (2024 Feb 8)
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26. Klein P, ..., Ramos A. m6a methylation orchestrates IMP1 regulation of microtubules during human neuronal differentiation. Nat Commun (2024 Jun 6)
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27. Kojima R, ..., Svenningsson P. Secretome Analyses Identify FKBP4 as a GBA1-Associated Protein in CSF and iPS Cells from Parkinson's Disease Patients with GBA1 Mutations. Int J Mol Sci (2024 Jan 4)
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28. Lee SW, ..., Yoo AS. Longitudinal modeling of human neuronal aging reveals the contribution of the RCAN1-TFEB pathway to Huntington's disease neurodegeneration. Nat Aging (2024 Jan)
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29. Liu ML, ..., Zhang CL. Screens in aging-relevant human ALS-motor neurons identify MAP4Ks as therapeutic targets for the disease. Cell Death Dis (2024 Jan 4)
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30. Louessard M, ..., Perrier AL. Mono- and Biallelic Inactivation of Huntingtin Gene in Patient-Specific Induced Pluripotent Stem Cells Reveal HTT Roles in Striatal Development and Neuronal Functions. J Huntingtons Dis (2024)
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31. Marques C, ..., Wainger BJ. Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia. Acta Neuropathol (2024 Mar 13)
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32. Minnella A, ..., Trimmer JK. Targeting ferroptosis with the lipoxygenase inhibitor PTC-041 as a therapeutic strategy for the treatment of Parkinson's disease. PLoS One (2024)
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33. Narasipura SD, ..., Mamede JI. HIV-1 infection promotes neuroinflammation and neuron pathogenesis in novel microglia-containing cerebral organoids. bioRxiv (2024 Jun 20)
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34. Oh YM, ..., Lee SW. Patient-derived neuron model: Capturing age-dependent adult-onset degenerative pathology in Huntington's disease. Mol Cells (2024 Apr)
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35. Paryani F, ..., Al-Dalahmah O. Multi-omic analysis of Huntington's disease reveals a compensatory astrocyte state. Nat Commun (2024 Aug 8)
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36. Patel R, ..., Sproul AA. Reduced SH3RF3 may protect against Alzheimer's disease by lowering microglial pro-inflammatory responses via modulation of JNK and NFkB signaling. bioRxiv (2024 Jun 28)
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37. Prem S, ..., DiCicco-Bloom E. Dysregulation of mTOR signaling mediates common neurite and migration defects in both idiopathic and 16p11.2 deletion autism neural precursor cells. Elife (2024 Mar 25)
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38. R AB, ..., Upadhya D. Cell-specific extracellular vesicle-encapsulated exogenous GABA controls seizures in epilepsy. Stem Cell Res Ther (2024 Apr 19)
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39. Sevigny J, ..., Hefti F. Progranulin AAV gene therapy for frontotemporal dementia: translational studies and phase 1/2 trial interim results. Nat Med (2024 May)
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40. Sharma D, ..., Tao YX. NT-3 contributes to chemotherapy-induced neuropathic pain through TrkC-mediated CCL2 elevation in DRG neurons. EMBO Rep (2024 Apr 9)
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41. Shin M, ..., Choi JW. Human Motor System-Based Biohybrid Robot-On-a-Chip for Drug Evaluation of Neurodegenerative Disease. Adv Sci (Weinh) (2024 Jan)
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42. Soubannier V, ..., Stifani S. Early nuclear phenotypes and reactive transformation in human iPSC-derived astrocytes from ALS patients with SOD1 mutations. Glia (2024 Aug 2)
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43. Sun J, ..., Prowse A. Analysis of three characterization assays reveals ddPCR of LIN28A as the most sensitive for the detection of residual pluripotent stem cells in cellular therapy products. Cytotherapy (2024 May 31)
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44. Sun Z, ..., Chiba-Falek O. Neuronal-type-specific epigenome editing to decrease SNCA expression: Implications for precision medicine in synucleinopathies. Mol Ther Nucleic Acids (2024 Mar 12)
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45. Suzuki H, ..., Inoue H. Mutant α-synuclein causes death of human cortical neurons via ERK1/2 and JNK activation. Mol Brain (2024 Mar 5)
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46. Szebényi K, ..., Lakatos A. Inhibition of PHLDA3 expression in human superoxide dismutase 1-mutant amyotrophic lateral sclerosis astrocytes protects against neurotoxicity. Brain Commun (2024)
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47. Wildey A, ..., Karanu F. Reduction of Activin A gives rise to comparable expression of key definitive endoderm and mature beta cell markers. Regen Med (2024 Jan)
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48. Zhang W, ..., Chen JF. Impaired phase separation and nucleolar functions in hiPSC models of SNORD118-related ribosomopathies. iScience (2024 Aug 16)
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49. Ahn HW, ..., Levin HL. Retrotransposon insertions associated with risk of neurologic and psychiatric diseases. EMBO Rep (2023 Jan 9)
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50. Allen AG, ..., Zuris JA. A highly efficient transgene knock-in technology in clinically relevant cell types. Nat Biotechnol (2023 May 1)
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51. Arslan U, ..., Orlova VV. Vascularized hiPSC-derived 3D cardiac microtissue on chip. Stem Cell Reports (2023 Jul 11)
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52. Badu-Mensah A, ..., Hickman JJ. The Effect of Skeletal Muscle-Specific Creatine Treatment on ALS NMJ Integrity and Function. Int J Mol Sci (2023 Aug 31)
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53. Becerra-Calixto A, ..., Soto C. Lewy Body-like Pathology and Loss of Dopaminergic Neurons in Midbrain Organoids Derived from Familial Parkinson's Disease Patient. Cells (2023 Feb 15)
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54. Bharat V, ..., Wang X. A mitochondrial inside-out iron-calcium signal reveals drug targets for Parkinson's disease. Cell Rep (2023 Dec 26)
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55. Carido M, ..., Karl MO. Reliability of human retina organoid generation from hiPSC-derived neuroepithelial cysts. Front Cell Neurosci (2023)
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56. Chin RM, ..., Hertz NT. Pharmacological PINK1 activation ameliorates Pathology in Parkinson's Disease models. bioRxiv (2023 Feb 15)
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57. Fang L, ..., Wang K. Haplotyping SNPs for allele-specific gene editing of the expanded huntingtin allele using long-read sequencing. HGG Adv (2023 Jan 12)
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58. Fukushi M, ..., Sakaguchi T. Optineurin deficiency impairs autophagy to cause interferon beta overproduction and increased survival of mice following viral infection. PLoS One (2023)
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59. Gonzalez H, ..., Al-Harthi L. An Efficient and Cost-Effective Approach to Generate Functional Human Inducible Pluripotent Stem Cell-Derived Astrocytes. Cells (2023 Sep 26)
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60. Guo X, ..., Hickman JJ. Human IPSC-Derived PreBötC-Like Neurons and Development of an Opiate Overdose and Recovery Model. Adv Biol (Weinh) (2023 Sep 7)
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61. Gutiérrez-Garcia R, ..., Vilchez D. G3BP1-dependent mechanism suppressing protein aggregation in Huntington's models and its demise upon stress granule assembly. Hum Mol Genet (2023 May 5)
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62. Horvath JD, ..., Dickson EJ. α-Synuclein-dependent increases in PIP5K1γ drive inositol signaling to promote neurotoxicity. Cell Rep (2023 Oct 31)
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63. Huang H, ..., Lennikov A. Association of Placental Growth Factor and Angiopoietin in Human Retinal Endothelial Cell-Pericyte co-Cultures and iPSC-Derived Vascular Organoids. Curr Eye Res (2023 Mar)
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64. Hung ST, ..., Ichida JK. PIKFYVE inhibition mitigates disease in models of diverse forms of ALS. Cell (2023 Feb 16)
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65. Iba M, ..., Masliah E. Inhibition of p38α MAPK restores neuronal p38γ MAPK and ameliorates synaptic degeneration in a mouse model of DLB/PD. Sci Transl Med (2023 May 10)
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66. Jangir H, ..., Hickman JJ. Mimicking the Tendon Microenvironment to Enhance Skeletal Muscle Adhesion and Longevity in a Functional Microcantilever Platform. ACS Biomater Sci Eng (2023 Aug 14)
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67. Joachimiak P, ..., Fiszer A. Allele-specific quantitation of ATXN3 and HTT transcripts in polyQ disease models. BMC Biol (2023 Feb 1)
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68. Jorfi M, ..., Tanzi RE. Infiltrating CD8(+) T cells exacerbate Alzheimer's disease pathology in a 3D human neuroimmune axis model. Nat Neurosci (2023 Sep)
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69. Kalra J, ..., Kalra J. Crosslink between mutations in mitochondrial genes and brain disorders: implications for mitochondrial-targeted therapeutic interventions. Neural Regen Res (2023 Jan)
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70. Kamienieva I, ..., Szczepanowska J. In search for mitochondrial biomarkers of Parkinson's disease: Findings in parkin-mutant human fibroblasts. Biochim Biophys Acta Mol Basis Dis (2023 Oct)
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71. Kim J, ..., Daadi MM. LRRK2 Attenuates Antioxidant Response in Familial Parkinson's Disease Derived Neural Stem Cells. Cells (2023 Oct 31)
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72. Kim MS, ..., Lee G. Advanced human iPSC-based preclinical model for Parkinson's disease with optogenetic alpha-synuclein aggregation. Cell Stem Cell (2023 Jul 6)
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73. Kim MY, ..., Han S. Trametinib activates endogenous neurogenesis and recovers neuropathology in a model of Alzheimer's disease. Exp Mol Med (2023 Oct)
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74. Krzystek TJ, ..., Gunawardena S. HTT (huntingtin) and RAB7 co-migrate retrogradely on a signaling LAMP1-containing late endosome during axonal injury. Autophagy (2023 Apr)
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75. Labrador-Garrido A, ..., Dzamko N. Live cell in situ lysosomal GCase activity correlates to alpha-synuclein levels in human differentiated neurons with LRRK2 and GBA1 mutations. Front Cell Neurosci (2023)
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76. Lee SW, ..., Yoo AS. Longitudinal modeling of human neuronal aging identifies RCAN1-TFEB pathway contributing to neurodegeneration of Huntington's disease. Res Sq (2023 May 9)
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77. Lee Y, ..., Seong IS. Huntingtin turnover: modulation of huntingtin degradation by cAMP-dependent protein kinase A (PKA) phosphorylation of C-HEAT domain Ser2550. Hum Mol Genet (2023 Jan 1)
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78. Leon KE, ..., Ott M. Nuclear accumulation of host transcripts during Zika Virus Infection. PLoS Pathog (2023 Jan)
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79. Liaudanskaya V, ..., Kaplan DL. Mitochondria dysregulation contributes to secondary neurodegeneration progression post-contusion injury in human 3D in vitro triculture brain tissue model. Cell Death Dis (2023 Aug 3)
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80. Linares GR, ..., Ichida JK. SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS. Cell Stem Cell (2023 Feb 2)
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81. Liu ML, ..., Zhang CL. Chemical screens in aging-relevant human motor neurons identify MAP4Ks as therapeutic targets for amyotrophic lateral sclerosis. bioRxiv (2023 Jul 21)
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82. Masmoudi F, ..., Buti L. Evaluation of 3D Human Intestinal Organoids as a Platform for EV-A71 Antiviral Drug Discovery. Cells (2023 Apr 12)
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83. Mesa H, ..., Zhang Q. Human neurons lacking amyloid precursor protein exhibit cholesterol-associated developmental and presynaptic deficits. J Cell Physiol (2023 Mar 26)
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84. Mubariz F, ..., Awad O. Deregulation of mTORC1-TFEB axis in human iPSC model of GBA1-associated Parkinson's disease. Front Neurosci (2023)
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85. Nim S, ..., Kim PM. Disrupting the α-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson's disease. Nat Commun (2023 Apr 19)
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86. Nimbalkar S, ..., Hickman JJ. Development of a functional human induced pluripotent stem cell-derived nociceptor MEA system as a pain model for analgesic drug testing. Front Cell Dev Biol (2023)
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210. Badu-Mensah A, ..., Hickman JJ. Functional skeletal muscle model derived from SOD1-mutant ALS patient iPSCs recapitulates hallmarks of disease progression. Sci Rep (2020 Aug 31)
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212. Candelario KM, ..., Steindler DA. Exosome/microvesicle content is altered in leucine-rich repeat kinase 2 mutant induced pluripotent stem cell-derived neural cells. J Comp Neurol (2020 May)
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224. García-León JA, ..., Verfaillie CM. Generation of oligodendrocytes and establishment of an all-human myelinating platform from human pluripotent stem cells. Nat Protoc (2020 Nov)
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226. Guo X, ..., Hickman JJ. A Human-Based Functional NMJ System for Personalized ALS Modeling and Drug Testing. Adv Ther (Weinh) (2020 Nov)
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229. Korecka JA, ..., Hastings ML. Splice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic Mice. Mol Ther Nucleic Acids (2020 Sep 4)
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231. Li S, ..., Lu B. Altered MICOS Morphology and Mitochondrial Ion Homeostasis Contribute to Poly(GR) Toxicity Associated with C9-ALS/FTD. Cell Rep (2020 Aug 4)
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232. Mannhardt I, ..., Eschenhagen T. Comparison of 10 Control hPSC Lines for Drug Screening in an Engineered Heart Tissue Format. Stem Cell Reports (2020 Oct 13)
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253. Blackford SJI, ..., Rashid ST. Validation of Current Good Manufacturing Practice Compliant Human Pluripotent Stem Cell-Derived Hepatocytes for Cell-Based Therapy. Stem Cells Transl Med (2019 Feb)
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254. Bredenkamp N, ..., Guo G. The Cell-Surface Marker Sushi Containing Domain 2 Facilitates Establishment of Human Naive Pluripotent Stem Cells. Stem Cell Reports (2019 Jun 11)
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255. Burbulla LF, ..., Krainc D. A modulator of wild-type glucocerebrosidase improves pathogenic phenotypes in dopaminergic neuronal models of Parkinson's disease. Sci Transl Med (2019 Oct 16)
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256. Cuddy LK, ..., Mazzulli JR. Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by α-Synuclein. Neuron (2019 Dec 4)
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257. Custer SK, ..., Androphy EJ. Abnormal Golgi morphology and decreased COPI function in cells with low levels of SMN. Brain Res (2019 Mar 1)
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258. de Graaf MNS, ..., Orlova VV. Scalable microphysiological system to model three-dimensional blood vessels. APL Bioeng (2019 Jun)
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259. Goodman LD, ..., Bonini NM. Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD. Nat Neurosci (2019 Jun)
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260. Hsieh CH, ..., Wang X. Miro1 Marks Parkinson's Disease Subset and Miro1 Reducer Rescues Neuron Loss in Parkinson's Models. Cell Metab (2019 Dec 3)
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261. Hu D, ..., Qi X. Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity. Acta Neuropathol (2019 Jun)
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265. Keskin S, ..., Evers MM. AAV5-miHTT Lowers Huntingtin mRNA and Protein without Off-Target Effects in Patient-Derived Neuronal Cultures and Astrocytes. Mol Ther Methods Clin Dev (2019 Dec 13)
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266. Kim H, ..., Jiang P. Pluripotent Stem Cell-Derived Cerebral Organoids Reveal Human Oligodendrogenesis with Dorsal and Ventral Origins. Stem Cell Reports (2019 May 14)
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267. Kim J, ..., Daadi MM. Non-cell autonomous mechanism of Parkinson's disease pathology caused by G2019S LRRK2 mutation in Ashkenazi Jewish patient: Single cell analysis. Brain Res (2019 Nov 1)
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268. Kulcenty K, ..., Suchorska WM. MicroRNA Profiling During Neural Differentiation of Induced Pluripotent Stem Cells. Int J Mol Sci (2019 Jul 26)
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272. Martier R, ..., Konstantinova P. Targeting RNA-Mediated Toxicity in C9orf72 ALS and/or FTD by RNAi-Based Gene Therapy. Mol Ther Nucleic Acids (2019 Jun 7)
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273. Martier R, ..., Evers MM. Development of an AAV-Based MicroRNA Gene Therapy to Treat Machado-Joseph Disease. Mol Ther Methods Clin Dev (2019 Dec 13)
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274. Martier R, ..., Konstantinova P. Artificial MicroRNAs Targeting C9orf72 Can Reduce Accumulation of Intra-nuclear Transcripts in ALS and FTD Patients. Mol Ther Nucleic Acids (2019 Mar 1)
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275. Ouchi R, ..., Takebe T. Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids. Cell Metab (2019 Aug 6)
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276. Page S, ..., Al-Ahmad A. Oxygen-Glucose Deprivation/Reoxygenation-Induced Barrier Disruption at the Human Blood-Brain Barrier is Partially Mediated Through the HIF-1 Pathway. Neuromolecular Med (2019 Dec)
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277. Ren C, ..., Liu CF. A compendious summary of Parkinson's disease patient-derived iPSCs in the first decade. Ann Transl Med (2019 Nov)
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278. Sarraf SA, ..., Pickrell AM. PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis. Cell Rep (2019 Oct 1)
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280. Tagliafierro L, ..., Chiba-Falek O. Multiplication of the SNCA locus exacerbates neuronal nuclear aging. Hum Mol Genet (2019 Feb 1)
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292. Connolly B, ..., Subramanian RR. SERPINA1 mRNA as a Treatment for Alpha-1 Antitrypsin Deficiency. J Nucleic Acids (2018)
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293. Fog CK, ..., Kirkegaard T. The heat shock protein amplifier arimoclomol improves refolding, maturation and lysosomal activity of glucocerebrosidase. EBioMedicine (2018 Dec)
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294. Fontaine KA, ..., Ott M. The Cellular NMD Pathway Restricts Zika Virus Infection and Is Targeted by the Viral Capsid Protein. mBio (2018 Nov 6)
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295. Ho DH, ..., Seol W. LRRK2 impairs autophagy by mediating phosphorylation of leucyl-tRNA synthetase. Cell Biochem Funct (2018 Dec)
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304. Luisier R, ..., Patani R. Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS. Nat Commun (2018 May 22)
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309. Milanese C, ..., Mastroberardino PG. Mitochondrial Complex I Reversible S-Nitrosation Improves Bioenergetics and Is Protective in Parkinson's Disease. Antioxid Redox Signal (2018 Jan 1)
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311. Nguyen M, ..., Krainc D. LRRK2 phosphorylation of auxilin mediates synaptic defects in dopaminergic neurons from patients with Parkinson's disease. Proc Natl Acad Sci U S A (2018 May 22)
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314. Pavoni S, ..., Yates F. Small-molecule induction of Aβ-42 peptide production in human cerebral organoids to model Alzheimer's disease associated phenotypes. PLoS One (2018)
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316. Romano G, ..., Feiguin F. Downregulation of glutamic acid decarboxylase in Drosophila TDP-43-null brains provokes paralysis by affecting the organization of the neuromuscular synapses. Sci Rep (2018 Jan 29)
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317. Shaltouki A, ..., Wang X. Alpha-synuclein delays mitophagy and targeting Miro rescues neuron loss in Parkinson's models. Acta Neuropathol (2018 Oct)
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321. Victor MB, ..., Yoo AS. Striatal neurons directly converted from Huntington's disease patient fibroblasts recapitulate age-associated disease phenotypes. Nat Neurosci (2018 Mar)
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322. Zou L, ..., Zhan X. The Effects of Quinine on Neurophysiological Properties of Dopaminergic Neurons. Neurotox Res (2018 Jul)
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323. Zunke F, ..., Mazzulli JR. Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide. Neuron (2018 Jan 3)
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324. Abernathy DG, ..., Yoo AS. MicroRNAs Induce a Permissive Chromatin Environment that Enables Neuronal Subtype-Specific Reprogramming of Adult Human Fibroblasts. Cell Stem Cell (2017 Sep 7)
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325. Al-Ahmad AJ, ..., Al-Ahmad AJ. Comparative study of expression and activity of glucose transporters between stem cell-derived brain microvascular endothelial cells and hCMEC/D3 cells. Am J Physiol Cell Physiol (2017 Oct 1)
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326. Ando M, ..., Springer W. The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity. Mol Neurodegener (2017 Apr 24)
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327. Bhinge A, ..., Stanton LW. Genetic Correction of SOD1 Mutant iPSCs Reveals ERK and JNK Activated AP1 as a Driver of Neurodegeneration in Amyotrophic Lateral Sclerosis. Stem Cell Reports (2017 Apr 11)
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328. Chao MJ, ..., Lee JM. Haplotype-based stratification of Huntington's disease. Eur J Hum Genet (2017 Nov)
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329. Chen MZ, ..., Hatters DM. A thiol probe for measuring unfolded protein load and proteostasis in cells. Nat Commun (2017 Sep 7)
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330. Core JQ, ..., Grosberg A. Age of heart disease presentation and dysmorphic nuclei in patients with LMNA mutations. PLoS One (2017)
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331. Donlin-Asp PG, ..., Rossoll W. The Survival of Motor Neuron Protein Acts as a Molecular Chaperone for mRNP Assembly. Cell Rep (2017 Feb 14)
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332. Dzamko N, ..., Halliday GM. Toll-like receptor 2 is increased in neurons in Parkinson's disease brain and may contribute to alpha-synuclein pathology. Acta Neuropathol (2017 Feb)
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333. Hall CE, ..., Patani R. Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS. Cell Rep (2017 May 30)
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334. Heman-Ackah SM, ..., Wood MJA. Alpha-synuclein induces the unfolded protein response in Parkinson's disease SNCA triplication iPSC-derived neurons. Hum Mol Genet (2017 Nov 15)
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335. Konrad C, ..., Manfredi G. Fibroblast bioenergetics to classify amyotrophic lateral sclerosis patients. Mol Neurodegener (2017 Oct 24)
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336. Lavado A, ..., Hickman JJ. Evaluation of Holistic Treatment for ALS Reveals Possible Mechanism and Therapeutic Potential. Int J Pharm Pharm Res (2017 Dec)
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337. Maiuri T, ..., Truant R. Huntingtin is a scaffolding protein in the ATM oxidative DNA damage response complex. Hum Mol Genet (2017 Jan 15)
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338. Malloy KE, ..., Daadi MM. Magnetic Resonance Imaging-Guided Delivery of Neural Stem Cells into the Basal Ganglia of Nonhuman Primates Reveals a Pulsatile Mode of Cell Dispersion. Stem Cells Transl Med (2017 Mar)
[PubMed 28297573] [PMC free article] [DOI 10.5966/sctm.2016-0269] [Related Cell Line IDs: ND29802]
339. Monteys AM, ..., Davidson BL. CRISPR/Cas9 Editing of the Mutant Huntingtin Allele In Vitro and In Vivo. Mol Ther (2017 Jan 4)
[PubMed 28129107] [PMC free article] [DOI 10.1016/j.ymthe.2016.11.010] [Related Cell Line IDs: ND31551, ND33392]
340. Oleksiewicz U, ..., Wiznerowicz M. TRIM28 and Interacting KRAB-ZNFs Control Self-Renewal of Human Pluripotent Stem Cells through Epigenetic Repression of Pro-differentiation Genes. Stem Cell Reports (2017 Dec 12)
[PubMed 29198826] [PMC free article] [DOI 10.1016/j.stemcr.2017.10.031] [Related Cell Line IDs: ND41658]
341. Pandya H, ..., Park JK. Differentiation of human and murine induced pluripotent stem cells to microglia-like cells. Nat Neurosci (2017 May)
[PubMed 28253233] [PMC free article] [DOI 10.1038/nn.4534] [Related External Line IDs: NCRM-5 (NHCDR line ND50031) (RMP Cell Line ID)]
342. Patel R, ..., Al-Ahmad AJ. Isogenic blood-brain barrier models based on patient-derived stem cells display inter-individual differences in cell maturation and functionality. J Neurochem (2017 Jul)
[PubMed 28397247] [DOI 10.1111/jnc.14040] [Related Google Scholar Queries: "coriell" "ninds" "ipsc" OR "fibroblast", "nhcdr", "repository" "ninds" "ipsc" OR "fibroblast"]
343. Quinti L, ..., Kazantsev AG. KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients. Proc Natl Acad Sci U S A (2017 Jun 6)
[PubMed 28533375] [PMC free article] [DOI 10.1073/pnas.1614943114] [Related Cell Line IDs: ND38548, ND38551, ND38554]
344. Schwab AJ, ..., Ebert AD. Decreased Sirtuin Deacetylase Activity in LRRK2 G2019S iPSC-Derived Dopaminergic Neurons. Stem Cell Reports (2017 Dec 12)
[PubMed 29129681] [PMC free article] [DOI 10.1016/j.stemcr.2017.10.010] [Related Cell Line IDs: ND35367, ND40018, ND40019]
345. Son MY, ..., Kim J. Distinctive genomic signature of neural and intestinal organoids from familial Parkinson's disease patient-derived induced pluripotent stem cells. Neuropathol Appl Neurobiol (2017 Dec)
[PubMed 28235153] [DOI 10.1111/nan.12396] [Related Cell Line IDs: ND29492, ND33879, ND38262]
346. Szlachcic WJ, ..., Figiel M. The Generation of Mouse and Human Huntington Disease iPS Cells Suitable for In vitro Studies on Huntingtin Function. Front Mol Neurosci (2017)
[PubMed 28848389] [PMC free article] [DOI 10.3389/fnmol.2017.00253] [Related Cell Line IDs: ND42224, ND42228, ND42245]
347. Tagliafierro L, ..., Chiba-Falek O. Genetic analysis of α-synuclein 3' untranslated region and its corresponding microRNAs in relation to Parkinson's disease compared to dementia with Lewy bodies. Alzheimers Dement (2017 Nov)
[PubMed 28431219] [PMC free article] [DOI 10.1016/j.jalz.2017.03.001] [Related Cell Line IDs: ND34391]
348. Takata K, ..., Ginhoux F. Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function. Immunity (2017 Jul 18)
[PubMed 28723550] [DOI 10.1016/j.immuni.2017.06.017] [Related Cell Line IDs: ND36997]
349. Teves JMY, ..., Madhavan L. Parkinson's Disease Skin Fibroblasts Display Signature Alterations in Growth, Redox Homeostasis, Mitochondrial Function, and Autophagy. Front Neurosci (2017)
[PubMed 29379409] [PMC free article] [DOI 10.3389/fnins.2017.00737] [Related Cell Line IDs: ND32973]
350. Vasquez V, ..., Hegde ML. Chromatin-Bound Oxidized α-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson's Disease. J Alzheimers Dis (2017)
[PubMed 28731447] [PMC free article] [DOI 10.3233/JAD-170342] [Related Cell Line IDs: ND34391]
351. Verma M, ..., Chu CT. Mitochondrial Calcium Dysregulation Contributes to Dendrite Degeneration Mediated by PD/LBD-Associated LRRK2 Mutants. J Neurosci (2017 Nov 15)
[PubMed 29038245] [PMC free article] [DOI 10.1523/JNEUROSCI.3791-16.2017] [Related Cell Line IDs: ND32975, ND33879, ND34769]
352. Wang L, ..., Liu GH. CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs. Protein Cell (2017 May)
[PubMed 28401346] [PMC free article] [DOI 10.1007/s13238-017-0397-3] [Related Cell Line IDs: ND29149, ND29563]
353. Xu X, ..., Pouladi MA. Reversal of Phenotypic Abnormalities by CRISPR/Cas9-Mediated Gene Correction in Huntington Disease Patient-Derived Induced Pluripotent Stem Cells. Stem Cell Reports (2017 Mar 14)
[PubMed 28238795] [PMC free article] [DOI 10.1016/j.stemcr.2017.01.022] [Related Cell Line IDs: ND36997, ND36999]
354. Zhong P, ..., Feng J. Dopamine Induces Oscillatory Activities in Human Midbrain Neurons with Parkin Mutations. Cell Rep (2017 May 2)
[PubMed 28467897] [PMC free article] [DOI 10.1016/j.celrep.2017.04.023] [Related Cell Line IDs: ND30171]
355. Borgs L, ..., Nguyen L. Dopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects. Sci Rep (2016 Sep 19)
[PubMed 27640816] [PMC free article] [DOI 10.1038/srep33377] [Related Cell Line IDs: ND29370]
356. Cho KJ, ..., Hancock JF. Inhibition of Acid Sphingomyelinase Depletes Cellular Phosphatidylserine and Mislocalizes K-Ras from the Plasma Membrane. Mol Cell Biol (2016 Jan 15)
[PubMed 26572827] [PMC free article] [DOI 10.1128/MCB.00719-15] [Related Cell Line IDs: ND29510]
357. Heman-Ackah SM, ..., Wood MJ. Precision Modulation of Neurodegenerative Disease-Related Gene Expression in Human iPSC-Derived Neurons. Sci Rep (2016 Jun 24)
[PubMed 27341390] [PMC free article] [DOI 10.1038/srep28420] [Related External Line IDs: NCRM-1 (NHCDR line ND50028) (RMP Cell Line ID), NCRM-5 (NHCDR line ND50031) (RMP Cell Line ID)]
358. Hsieh CH, ..., Wang X. Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson's Disease. Cell Stem Cell (2016 Dec 1)
[PubMed 27618216] [PMC free article] [DOI 10.1016/j.stem.2016.08.002] [Related Cell Line IDs: ND39896, ND41866]
359. Lin L, ..., Stanton LW. Molecular Features Underlying Neurodegeneration Identified through In Vitro Modeling of Genetically Diverse Parkinson's Disease Patients. Cell Rep (2016 Jun 14)
[PubMed 27264186] [DOI 10.1016/j.celrep.2016.05.022] [Related Cell Line IDs: ND34391, ND35367, ND38477, ND39896, ND40018]
360. Liu ML, ..., Zhang CL. Direct Lineage Reprogramming Reveals Disease-Specific Phenotypes of Motor Neurons from Human ALS Patients. Cell Rep (2016 Jan 5)
[PubMed 26725112] [PMC free article] [DOI 10.1016/j.celrep.2015.12.018] [Related Cell Line IDs: ND29563, ND39027, ND40077]
361. Mazzulli JR, ..., Krainc D. Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons. J Neurosci (2016 Jul 20)
[PubMed 27445146] [PMC free article] [DOI 10.1523/JNEUROSCI.0628-16.2016] [Related Cell Line IDs: ND39896]
362. Mungenast AE, ..., Tsai LH. Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cells. Mol Cell Neurosci (2016 Jun)
[PubMed 26657644] [PMC free article] [DOI 10.1016/j.mcn.2015.11.010] [Related Cell Line IDs: ND40076]
363. Narayan M, ..., Jinwal UK. Identification of Apo B48 and other novel biomarkers in amyotrophic lateral sclerosis patient fibroblasts. Biomark Med (2016 May)
[PubMed 27141953] [DOI 10.2217/bmm-2016-0025] [Related Cell Line IDs: ND29178, ND29194, ND29422, ND29509, ND29774, ND32947, ND34769, ND36091, ND38530]
364. Noormohammadi A, ..., Vilchez D. Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan. Nat Commun (2016 Nov 28)
[PubMed 27892468] [PMC free article] [DOI 10.1038/ncomms13649] [Related Cell Line IDs: ND30014, ND33392, ND36997, ND36998, ND36999, ND41656, ND42229, ND42242]
365. Pryde KR, ..., Schapira AH. PINK1 disables the anti-fission machinery to segregate damaged mitochondria for mitophagy. J Cell Biol (2016 Apr 25)
[PubMed 27091447] [PMC free article] [DOI 10.1083/jcb.201509003] [Related Cell Line IDs: ND40066]
366. Raja WK, ..., Tsai LH. Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer's Disease Phenotypes. PLoS One (2016)
[PubMed 27622770] [PMC free article] [DOI 10.1371/journal.pone.0161969] [Related Cell Line IDs: ND34732]
367. Sepe S, ..., Mastroberardino PG. Inefficient DNA Repair Is an Aging-Related Modifier of Parkinson's Disease. Cell Rep (2016 May 31)
[PubMed 27210754] [PMC free article] [DOI 10.1016/j.celrep.2016.04.071] [Related Cell Line IDs: ND32975, ND32976, ND33879]
368. Tousley A, ..., Kegel-Gleason KB. Induced Pluripotent Stem Cells in Huntington's Disease Research: Progress and Opportunity. J Huntingtons Dis (2016 Jun 28)
[PubMed 27372054] [PMC free article] [DOI 10.3233/JHD-160199] [Related Cell Line IDs: ND41658, ND42223, ND42224, ND42228, ND42230, ND42245]
369. Urbanek MO, ..., Krzyzosiak WJ. RNA FISH for detecting expanded repeats in human diseases. Methods (2016 Apr 1)
[PubMed 26615955] [DOI 10.1016/j.ymeth.2015.11.017] [Related Cell Line IDs: ND41657, ND41658]
370. Vazquez-Arango P, ..., O'Reilly D. Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular disease. Nucleic Acids Res (2016 Dec 15)
[PubMed 27536002] [PMC free article] [DOI 10.1093/nar/gkw711] [Related Cell Line IDs: ND30625]
371. Zhou Q, ..., Bolotina VM. Impairment of PARK14-dependent Ca(2+) signalling is a novel determinant of Parkinson's disease. Nat Commun (2016 Jan 12)
[PubMed 26755131] [PMC free article] [DOI 10.1038/ncomms10332] [Related Google Scholar Queries: "coriell" "ninds" "ipsc" OR "fibroblast", "repository" "ninds" "ipsc" OR "fibroblast"]
372. Du ZW, ..., Zhang SC. Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells. Nat Commun (2015 Mar 25)
[PubMed 25806427] [PMC free article] [DOI 10.1038/ncomms7626] [Related Cell Line IDs: ND29149, ND35671]
373. Ho DH, ..., Seol W. Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expression. Mol Brain (2015 Sep 18)
[PubMed 26384650] [PMC free article] [DOI 10.1186/s13041-015-0145-7] [Related Cell Line IDs: ND29492]
374. Iovino M, ..., Spillantini MG. Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations. Brain (2015 Nov)
[PubMed 26220942] [PMC free article] [DOI 10.1093/brain/awv222] [Related Cell Line IDs: ND40076]
375. Khan TK, ..., Alkon DL. PKCε deficits in Alzheimer's disease brains and skin fibroblasts. J Alzheimers Dis (2015)
[PubMed 25125477] [DOI 10.3233/JAD-141221] [Related Cell Line IDs: ND27760, ND31618, ND34265]
376. Ring KL, ..., Ellerby LM. Genomic Analysis Reveals Disruption of Striatal Neuronal Development and Therapeutic Targets in Human Huntington's Disease Neural Stem Cells. Stem Cell Reports (2015 Dec 8)
[PubMed 26651603] [PMC free article] [DOI 10.1016/j.stemcr.2015.11.005] [Related Cell Line IDs: ND41656, ND42222]
377. Schwab AJ, ..., Ebert AD. Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson's Disease-Related LRRK2 G2019S Mutation. Stem Cell Reports (2015 Dec 8)
[PubMed 26651604] [PMC free article] [DOI 10.1016/j.stemcr.2015.11.004] [Related Cell Line IDs: ND34391, ND35367, ND40018, ND40019]
378. Su YC, ..., Qi X. Threonine 56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagy. Biochim Biophys Acta (2015 Jan)
[PubMed 25446991] [PMC free article] [DOI 10.1016/j.bbadis.2014.11.009] [Related Cell Line IDs: ND29802, ND33879]
379. Szlachcic WJ, ..., Figiel M. Huntington disease iPSCs show early molecular changes in intracellular signaling, the expression of oxidative stress proteins and the p53 pathway. Dis Model Mech (2015 Sep)
[PubMed 26092128] [PMC free article] [DOI 10.1242/dmm.019406] [Related Cell Line IDs: ND41658, ND42223, ND42224, ND42228, ND42230, ND42245]
380. Takahashi M, ..., Hohjoh H. Normalization of Overexpressed α-Synuclein Causing Parkinson's Disease By a Moderate Gene Silencing With RNA Interference. Mol Ther Nucleic Acids (2015 May 12)
[PubMed 25965551] [DOI 10.1038/mtna.2015.14] [Related Cell Line IDs: ND27760, ND29510]
381. York AG, ..., Bensinger SJ. Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling. Cell (2015 Dec 17)
[PubMed 26686653] [PMC free article] [DOI 10.1016/j.cell.2015.11.045] [Related Cell Line IDs: ND38530]
382. Bellani S, ..., Chieregatti E. GRP78 clustering at the cell surface of neurons transduces the action of exogenous alpha-synuclein. Cell Death Differ (2014 Dec)
[PubMed 25124556] [PMC free article] [DOI 10.1038/cdd.2014.111] [Related Cell Line IDs: ND27760]
383. Chen H, ..., Zhang SC. Modeling ALS with iPSCs reveals that mutant SOD1 misregulates neurofilament balance in motor neurons. Cell Stem Cell (2014 Jun 5)
[PubMed 24704493] [PMC free article] [DOI 10.1016/j.stem.2014.02.004] [Related Cell Line IDs: ND29149, ND35671]
384. Lu HF, ..., Wan AC. A defined xeno-free and feeder-free culture system for the derivation, expansion and direct differentiation of transgene-free patient-specific induced pluripotent stem cells. Biomaterials (2014 Mar)
[PubMed 24411336] [DOI 10.1016/j.biomaterials.2013.12.050] [Related Cell Line IDs: ND30116]
385. Sagal J, ..., Ying M. Proneural transcription factor Atoh1 drives highly efficient differentiation of human pluripotent stem cells into dopaminergic neurons. Stem Cells Transl Med (2014 Aug)
[PubMed 24904172] [PMC free article] [DOI 10.5966/sctm.2013-0213] [Related Cell Line IDs: ND27760]
386. Sanders LH, ..., Schüle B. LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction. Neurobiol Dis (2014 Feb)
[PubMed 24148854] [PMC free article] [DOI 10.1016/j.nbd.2013.10.013] [Related Cell Line IDs: ND34393, ND34394, ND35367]
387. Skibinski G, ..., Finkbeiner S. Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies. J Neurosci (2014 Jan 8)
[PubMed 24403142] [PMC free article] [DOI 10.1523/JNEUROSCI.2712-13.2014] [Related Cell Line IDs: ND35367]
388. Allen GF, ..., Ganley IG. Loss of iron triggers PINK1/Parkin-independent mitophagy. EMBO Rep (2013 Dec)
[PubMed 24176932] [PMC free article] [DOI 10.1038/embor.2013.168] [Related Cell Line IDs: ND29543]
389. Liu ML, ..., Zhang CL. Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons. Nat Commun (2013)
[PubMed 23873306] [PMC free article] [DOI 10.1038/ncomms3183] [Related Cell Line IDs: ND29563]
390. Lu J, ..., Zhang SC. Generation of integration-free and region-specific neural progenitors from primate fibroblasts. Cell Rep (2013 May 30)
[PubMed 23643533] [PMC free article] [DOI 10.1016/j.celrep.2013.04.004] [Related Cell Line IDs: ND32947]
391. Cooper O, ..., Isacson O. Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease. Sci Transl Med (2012 Jul 4)
[PubMed 22764206] [PMC free article] [DOI 10.1126/scitranslmed.3003985] [Related Cell Line IDs: ND29492, ND29802, ND30244, ND32944]
392. Egawa N, ..., Inoue H. Drug screening for ALS using patient-specific induced pluripotent stem cells. Sci Transl Med (2012 Aug 1)
[PubMed 22855461] [DOI 10.1126/scitranslmed.3004052] [Related Cell Line IDs: ND32947]
393. Wray S, ..., Hardy J. Creation of an open-access, mutation-defined fibroblast resource for neurological disease research. PLoS One (2012)
[PubMed 22952635] [PMC free article] [DOI 10.1371/journal.pone.0043099] [Related Google Scholar Queries: "coriell" "ninds" "ipsc" OR "fibroblast", "repository" "ninds" "ipsc" OR "fibroblast"]
394. Yagi T, ..., Suzuki N. Establishment of induced pluripotent stem cells from centenarians for neurodegenerative disease research. PLoS One (2012)
[PubMed 22848530] [PMC free article] [DOI 10.1371/journal.pone.0041572] [Related Cell Line IDs: ND27760]
395. Devine MJ, ..., Kunath T. Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus. Nat Commun (2011 Aug 23)
[PubMed 21863007] [PMC free article] [DOI 10.1038/ncomms1453] [Related Cell Line IDs: ND27760]
396. Serviddio G, ..., Vendemiale G. Principles and therapeutic relevance for targeting mitochondria in aging and neurodegenerative diseases. Curr Pharm Des (2011)
[PubMed 21718251] [DOI 10.2174/138161211796904740] [Related RUIDs: NN0004337, NN0004344]
These publications were found using a combination of automated
Google Scholar
searches and manual review. When possible, we show specific
identifiers, such as NHCDR cell line IDs, that were cited
in the text. In some cases, when no specific identifiers were found,
we instead show NHCDR-related terms. The terms are sometimes
provided in the form of Google Scholar queries that yield the publication, such as
"repository" "ninds" "ipsc" OR "fibroblast" (you can try this search
here).
If you have access to the full text of the publication (we provide links when possible),
you can search the text for the IDs and/or terms to determine exactly how NHCDR resources
were used in the publication.
We are grateful to SerpApi for providing critical data mining services used to produce this list.
This collection was formerly maintained at the Coriell Repository. While some papers may still reference Coriell, the cell line resources they used are now maintained at the NHCDR.
